Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1812, Issue 8, August 2011, Pages 1061-1067
ReviewNuclear receptors in renal disease☆
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Research highlights
► Several nuclear receptors are highly expressed in the kidney. ► Animal studies using activating ligands, knockout mice, or transgenic mice have shown that FXR, VDR, and PPARs play an important role in modulation of kidney disease. ► Several human trials are essentially in agreement with the animal studies. ► Activation of VDR, FXR, and PPARs modulates kidney disease by regulating lipid metabolism, inflammation, oxidative stress, and fibrosis. ► There are several additional nuclear receptors whose function in the kidney remain unknown.
Keywords
Diabetes
Nuclear hormone receptors
Renal disease
VDR
FXR
PPAR
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This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
Published by Elsevier B.V.