Original articleGeneral thoracicRisk Factors Associated With Lung Retransplantation: Evaluation of a Nationwide Registry Over a Quarter Century
Section snippets
Material and Methods
We performed a retrospective evaluation of data obtained from Scientific Registry of Transplant Recipients (SRTR) Standard Transplant Analysis and Research files provided by the United Network for Organ Sharing (UNOS). This comprised a data set of a prospectively collected open cohort of consecutive United States adult lung transplant recipients who had undergone lung transplantation between 1987 and 2012. The University of Pittsburgh Medical Center institutional review board (IRB) approved
Results
We identified 23,180 adults who received lung allografts, 791 (3.4%) of whom subsequently underwent lung retransplantation. After 1 year and 5 years of primary transplant, 210 (0.9%) and 582 (2.5%) patients underwent retransplantation. A total of 4,261 patients (18.4%) and 9,386 patients (40.5%) in the cohort were dead at 1 year and 5 years after the initial transplantation.
Table 1 compares recipient-related, donor-related, and transplant-related characteristics. Patients who underwent
Comment
An evaluation of the risk factors for retransplantation may better allow a prediction of which recipients may require repeat allocation of this scarce commodity. This should, in turn, allow for a means to better prepare for the eventuality. Numerous single-center accounts within the literature have identified chronic graft failure as the most justifiable indication for lung retransplantation. These suggest, in addition, that recipients undergoing retransplantation for BOS have an almost
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