P1.1 PHYSICAL ACTIVITY IS ASSOCIATED WITH FLOW-MEDIATED DILATATION IN FEMALES

DOI

10.1016/j.artres.2015.10.195How to use a DOI?

Abstract

Impairment of vascular endothelial function is an early sign of atherosclerosis. An active lifestyle is suggested to be positively associated with favorable endothelial function as opposed to a sedentary lifestyle.

The aim of this ongoing study (Lifestyle, Biomarkers and Atherosclerosis Study) is to investigate associations between vascular endothelial function and physical activity level in 1000 non-smokers without know disease aged 18-25 years. Preliminary data from the 317 first subjects with complete data will be reported here.

Flow-mediated dilation was assessed in a. brachialis by high-resolution ultrasound (Vivid e9) before and after 5-minutes occlusion, and time spent active (at moderate or vigorous intensity level) or sedentary was assessed by accelerometry (ActiGraph wGT3X-BT).

Females

n=226

Males

n=91

Gender differences

(P-value)

Age

BMI

Body fat (%)

Time spent active (min/day)

Time spent sedentary (min/day)

Flow Mediated Dilatation measures

Diameter, pre-stas (mm)

Increase, post-stas (mm)

Increase, post-stas (%)

21,8

22,4

27,8

45

514

3,16

0,28

8,9

21,8

22,9

15,0

45

524

3,74

0,28

7,5

1,00

0,14

<0,001

0,99

0,32

<0,001

0,96

<0,001

Multiple regression analyses show that time spent active is statistically associated with diameter increase (mm) and percentage increase (adjusted for pre-stas diameter) in females (beta coefficient = 0,144; p=0,032 and beta-coefficient=0,135; p= 0,041, respectively) but not in males. Time spent sedentary did not show any associations with the flow-mediated dilatation variables in neither females nor males.

In conclusion, already in young adulthood, an active lifestyle is associated with higher flow-mediated dilatation as a measure of endothelial function.

Open Access

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TY  - JOUR
AU  - Ulrika Ferberg*
AU  - Katya Matusevich
AU  - Gabriella Eliason
AU  - Maria Fernstom
AU  - Anita Hurtig-Wennlof
PY  - 2015
DA  - 2015/11/23
TI  - P1.1 PHYSICAL ACTIVITY IS ASSOCIATED WITH FLOW-MEDIATED DILATATION IN FEMALES
JO  - Artery Research
SP  - 3
EP  - 3
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.195
DO  - 10.1016/j.artres.2015.10.195
ID  - Ferberg*2015
ER  -