Editor’s Capsule Summary
What is already known on this topic
Accelerated diagnostic protocols for acute myocardial infarction using high-sensitivity cardiac troponin (hs-cTn) assays have been developed and validated in European and Australasian populations.
What question this study addressed
What is the diagnostic accuracy of hs-cTn accelerated protocols for acute myocardial infarction in a US emergency department population?
What this study adds to our knowledge
In a US population, hs-cTn accelerated protocols have high sensitivity at the rule-out threshold and high specificity at the rule-in threshold used in European studies.
How this is relevant to clinical practice
hs-cTn Accelerated protocols are validated in the US population and can be used to guide practice if the reported sensitivity and specificity are considered acceptable.