Editor's Capsule Summary
What is already known on this topic
Seizing children can develop apnea.
What question this study addressed
When is such apnea more likely?
What this study adds to our knowledge
In this multicenter retrospective study of 1,584 children with out-of-hospital seizures, predictors of the 71 who developed apnea were continuing seizure on emergency department arrival and receiving midazolam.
How this is relevant to clinical practice
Although apnea can result from both ongoing seizures and midazolam, these data suggest that the benefit of using midazolam to stop seizures in children outweighs the risk of persistent seizures.