Clinical ScienceLong-term risk of mesenteric ischemia in patients with inflammatory bowel disease: a 13-year nationwide cohort study in an Asian population
Section snippets
Data source
The nationwide cohort study was based on data obtained from the NHIRD and the Bureau of National Health Insurance. The NHIRD contains healthcare data of nearly 99% of the entire Taiwanese population (23 million) and is contracted with 97% of clinics and hospitals throughout the nation (http://nhird.nhri.org.tw/en/index.htm). We obtained longitudinal person-level data on medical care by linking an encrypted unique personal identification from 2 files: registry for beneficiaries and inpatient
Results
We identified 46,815 patients who were eligible for this study, with 9,363 patients in the IBD cohort and 37,452 patients in the non-IBD cohort. The mean follow-up periods were 6.44 ± 3.75 years in the IBD cohort and 7.18 ± 3.39 in the non-IBD cohort. The demographic characteristics are shown in Table 1. The mean ages for the IBD and non-IBD cohorts were 53.1 (standard deviation = 18.9) and 52.7 (standard deviation = 18.9) years (P = .04), respectively. More male patients were involved in this
Comments
This is the first study to address the long-term risk of mesenteric ischemia in patients with IBD based on nationwide data. This population-based cohort study shows that the long-term risk of mesenteric ischemia is significantly higher in patients with IBD, with an AHR of 6.43 (95% CI: 4.83 to 8.56) for mesenteric ischemia within 13 years, after accounting for mortality as the competing cause of risk and adjusting for multiple known confounding factors for mesenteric ischemia. Moreover, the HR
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Supported in part by the study projects of DMR-103-018 of China Medical University Hospital; Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW103-TDU-B-212-113002), Health and welfare surcharge of tobacco products, China Medical University Hospital Cancer Research Center of Excellence (MOHW103-TD-B-111-03, Taiwan); and International Research-Intensive Centers of Excellence in Taiwan (I-RiCE) (NSC101-2911-I-002-303). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study.
The authors declare no conflicts of interest.