Brief reportThe utility of estrogen receptor, progesterone receptor, and Her-2/neu status to predict survival in patients undergoing hepatic resection for breast cancer metastases
Section snippets
Methods
Between 1995 and 2004, 1147 liver-directed procedures were performed for primary or hepatic malignancies; 20 patients underwent hepatic resection, biopsy, or ablation for breast cancer metastases. The Saint John’s Health Center/John Wayne Cancer Institute Institutional Review Board granted human subject approval for a retrospective review of these patients. Variables measured were patient age at diagnosis of hepatic metastasis; tumor size and histology; axillary nodes affected; ER and PR status
Results
Patient and tumor characteristics are listed in Table 1. The mean follow-up after hepatic resection was 39 months. Median survival was 32 months; 2- and 5-year survival rates were 61% and 33%, respectively.
From the time of initial breast cancer diagnosis, survival was significantly greater in patients with ER-positive (9.58 vs. 7.60 years, P < .04) and PR-positive (11 vs. 7.18 years, P < .008) primary tumors, whereas the Her-2/neu status of the primary tumor did not reach statistical
Comments
Once breast cancer progresses to involve distant sites, survival is poor. The median survival for patients with hepatic metastases ranges from 1 to 25.3 months with palliative hormonal or chemotherapeutic treatment and supportive care [3], [4], [5], [6], [7], [8], [9]. A subset of patients, however, may benefit from resection even at this late stage. This assertion is supported by 5-year survival rates of 22% and median survival rates >30 months after resection of isolated breast hepatic
Acknowledgments
Supported by the Rod Fasone Memorial Cancer Fund (Indianapolis, IN); the Henry L. Guenther Foundation (Los Angeles, CA); the William Randolph Hearst Foundation (San Francisco, CA); the family of Jeanne and Eric Li and the Davidow Charitable Fund (Los Angeles, CA); the Ben B. and Joyce E. Eisenberg Foundation (Los Angeles, CA); the Fashion Footwear Association of New York Charitable Foundation (New York, NY); the Leslie and Susan Gonda (Goldschmied) Foundation (Los Angeles, CA); the John Wayne
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Impact of Hepatic Metastasectomy in the Multimodal Treatment of Metastatic Breast Cancer
2021, Journal of Surgical ResearchCitation Excerpt :In 2020, nearly 300,000 new diagnoses of breast cancer were projected among female patients in the United States.2 Approximately 5% of these women will present with metastases to the liver at the time of their primary breast cancer diagnosis.3-10 Median survival for patients with stage IV breast cancer and hepatic metastases ranges from 3-15 mo.3,5,7,11 Traditionally, any evidence of distant metastatic disease, including metastases isolated to the liver, has been treated with systemic therapy.
Solitary metastases
2018, The Breast: Comprehensive Management of Benign and Malignant DiseasesLiver Metastases From Breast Cancer: What Role for Surgery? Indications and Results
2017, Clinical Breast CancerCitation Excerpt :Likewise, the T-stage of primary tumor was not correlated with OS after surgery for LMBC.42,56 Based on our current scientific knowledge, the age of patients should not be considered as a criterion; the cutoff point of 50 years advocated by some authors may represent a divergent prognostic factor: a risk factor for younger patients (<50 years) according to Lubrano et al49 and Martinez et al,50 but a risk factor for older patients (>50 years) according to Dittmar et al.48 The best results after the resection of LMBC are obtained after applying criteria selection based on the following: