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Point-of-Care Echocardiography Improves Assessment of Volume Status in Cirrhosis and Hepatorenal Syndrome

https://doi.org/10.1016/j.amjms.2016.02.040Get rights and content

Abstract

The management of patients with cirrhosis along with acute kidney injury is complex and depends in large part on accurate assessment of intravascular volume status. Assessment of intravascular volume status by point-of-care echocardiography often relies solely on inferior vena cava size and variability evaluation; however, this parameter should be interpretated with an understanding of right ventricular function integrated with stroke volume and flow. Attempts to optimize intra-abdominal hemodynamics favorably are clearly problematic when physical examination findings or rudimentary assessments of central venous pressure or change in central venous pressure are used. Here, we have demonstrated the potential utility of point-of-care echocardiography to optimize the hemodynamic state in patients with decompensated cirrhosis along with acute kidney injury. This case is very unique and describes how this technique may have great promise in optimizing the intra-abdominal hemodynamics and predict the timing of large-volume paracentesis in patients with decompensated cirrhosis, which in turn can aid in promoting favorable renal recovery.

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Case Presentation

A 66-year-old woman with hepatitis C virus–related cirrhosis, portal hypertension, ascites, esophageal varices and chronic kidney disease (baseline creatinine of 1.7 mg/dL) presented with acute kidney injury (AKI) and altered mental status. She was believed to have hepatic encephalopathy and required intubation for airway protection on hospital day 2. Her serum creatinine level was 3.1 mg/dL at presentation. To manage her AKI, she received an aggressive volume-loading strategy with both

Discussion

The AKI in the setting of cirrhosis is a dreaded event because it is associated with significant morbidity and mortality.1 Accurately identifying the cause of AKI in patients with cirrhosis is difficult, primarily because the diagnosis of HRS must always be considered. The HRS remains a diagnosis of exclusion, made only after excluding other disorders, withholding diuretic therapy and after aggressive volume loading. This strategy often leads to significant delays in diagnosis and missed

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The authors have no financial or other conflicts of interest to disclose.

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