Clinical research studyEnterococcal endocarditis: 107 cases from the international collaboration on endocarditis merged database
Section snippets
Database
The creation of the International Collaboration on Endocarditis Merged Database has been previously described.21 Briefly, participating members of the International Collaboration on Endocarditis from 7 sites from 5 countries, including the United States (Philadelphia, PA and Durham, NC), United Kingdom (London), France (Marseille and Besancon), Sweden (Gothenburg), and Spain (Barcelona), submitted databases to the coordinating center, the Duke Clinical Research Institute, for inclusion in the
Results
The International Collaboration on Endocarditis Merged Database contains the records of 2212 patients with definite infective endocarditis. One thousand two hundred and eighty-five patients had left-sided native valve endocarditis, including 107 patients due to enterococci, 314 patients due to S. aureus, and 666 patients due to streptococci (Figure 1). The 107 enterococcal strains were distributed as follows: Enterococcus faecalis (n = 62, 58%), Enterococcus faecium (n = 4, 3%), Enterococcus
Discussion
This study includes 107 patients with enterococcal native valve endocarditis. The patients are diverse, coming from 7 centers in the United States and Europe. The breadth of the database allowed us to contrast patients with enterococcal endocarditis with meaningful comparison groups, including patients with endocarditis due to S. aureus and streptococci. This study provides an opportunity to examine and refine previous thoughts about enterococcal endocarditis.
Enterococcal endocarditis was
Acknowledgments
This study was supported in part by the following: National Institutes of Health grants K23 AI-01647 (VGF) and K23 HL70861-01 (CHC), AHA BGIA 0265405U (CHC), the Tenet Healthcare Foundation (Santa Barbara, CA)(EA), the Red Española de Investigación en Patología Infecciosa (V-2003-REDC14A-O)(JMM), the Fundación Privada Máximo Soriano Jiménez (Barcelona, Spain)(JMM), the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS, Barcelona Spain) (JMM).
From the International Collaboration
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No authors have any conflict of interest to disclose regarding the work presented in this manuscript.