Impact of Systolic Blood Pressure on Heart Failure Symptoms With Moderate Aortic Stenosis
Section snippets
Methods
This was a retrospective observational study. The study population was comprised of 947 patients with moderate AS (mean transaortic pressure gradient between 20-and 39-mm Hg on Doppler ultrasound) from the 2-dimensional transthoracic echocardiographic database of Cedars-Sinai Medical Center (Los Angeles, CA) from January 2014 to December 2015.
The exclusion criteria consisted of the following: age <18 years, reduced LV systolic function (LV ejection fraction <50%), peak aortic velocity ≥4.0 m/s,
Results
The baseline demographic and clinical characteristics of 317 patients with moderate AS (mean age 81±12 years), according to HF symptoms, are shown in Table 1. Of the patients, 217 (68%) were asymptomatic and 100 (32%) had HF symptoms. Among patients with HF symptoms, 56 (56%) had NYHA II, 39 (39%) had NYHA III, and 5 (5%) had NYHA IV. In total, 296 patients (93%) had hypertension, which confirmed the presence of a high prevalence of hypertension among patients with moderate AS. Compared with
Discussion
In this retrospective study, we reported 3 major findings as follows: (1) A total of 32% of patients with moderate AS had HF symptoms; (2) Patients with HF symptoms had a significantly higher systolic BP than asymptomatic patients, regardless of the use of antihypertensive treatment; (3) Systolic BP and LAV index were independently associated with HF symptoms in patients with moderate AS even after adjustment for clinical and echocardiographic associates.
The presence of HF symptoms is one of
Author Contributions
Mika Maeda: Conceptualization, Methodology, Writing – Review & Editing, Writing – Original Draft; Taku Omori: Writing – Review & Editing, Writing – Original Draft, Formal analysis; Shunsuke Kagawa: Data curation; Goki Uno: Data curation; Florian Rader: Writing – Review & Editing, Supervision; Robert J. Siegel: Supervision; Takahiro Shiota: Supervision, Conceptualization, Writing – Review & Editing, Writing – Original Draft.
Disclosures
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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Cited by (0)
Dr. Rader is a consultant at MyoKardia, Inc. and ReCor Medical.
Funding: There are no sources of funding to report