Impact of Macroprolactinemia on Cardiometabolic Effects of Atorvastatin in Women With Hypercholesterolemia
Section snippets
Methods
The study population was selected among adult women (aged 35 to 65 years) with elevated cholesterol levels, defined as total cholesterol concentrations more than 200 mg/dl and low-density lipoprotein (LDL) cholesterol concentrations above 130 mg/dl, complying with the lifestyle modification for more than 3 months before entering the study. The first group included 12 women meeting the following criteria of macroprolactinemia: (1) total prolactin levels more 40 ng/ml found on 2 different
Results
At baseline, there were no significant differences between the participants with and without macroprolactinemia in age, body mass index, smoking habits, fasting and 2-hour postload plasma glucose, glycated hemoglobin, plasma lipids, uric acid, fibrinogen and homocysteine (Table 1). Expectedly, both study groups differed in prolactin concentrations before polyethylene glycol precipitation and in macroprolactin content but not in prolactin concentrations after polyethylene glycol precipitation.
Discussion
Compared with control subjects, women with macroprolactinemia were characterized by increased circulating levels of hsCRP, higher values of HOMA1-IR and decreased levels of 25-hydroxyvitamin D. Similar differences were reported previously between women with elevated content of big-big prolactin not selected for plasma lipids and healthy young women with normal lipid levels.9 The participants of the present study were older (50 ± 8 years) than women participating in the previous one (34 ± 7
Disclosures
The authors declare that they have no conflict of interest.
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Funding:This work was not supported by any external sources of funding.
Ethical Approval:All procedures performed in the study were in accordance with the ethical standards of the institutional research committee and with the 1964 Declaration of Helsinki and its later amendments.
Institutional Approval: The study was approved by the Bioethical Committee of the Medical University of Silesia.