CardiomyopathySignificance and Determinants of Cardiac Troponin I in Patients With Obstructive Hypertrophic Cardiomyopathy
Section snippets
Methods
We recruited consecutive patients with obstructive HC who were evaluated in Fuwai Hospital (Beijing, China) from November 2008 to June 2013. All subjects underwent a comprehensive cardiac evaluation, including complete medical history, physical examination, 12-lead electrocardiography, 24-hour ambulatory electrocardiographic monitoring, TTE, blood examination, CMR, and coronary angiography. The diagnosis of HC was based on a maximum LV wall thickness ≥15 mm (or ≥13 mm with an unequivocal family
Results
One hundred forty-nine patients were included in the present study (92 men [62%]; age 47.4 ± 10.8 years; Table 1). The majority of them (85%) had severe dyspnea (New York Heart Association functional class III/IV). Syncope was present in 50 patients (34%). Forty-seven patients (32%) were complicated with hypertension. All subjects had significant LVOT obstruction (gradient ≥30 mm Hg), including 139 patients (93%) with obstruction at rest and the remaining 10 patients (7%) with latent
Discussion
In the present study, serum cTnI levels were elevated (≥0.04 ng/ml) in 28% of our patients. Both elevated cTnI and serum cTnI levels (as a continuous variable) were significantly associated with multiple parameters of disease severity, including LV hypertrophy (SWT, MWT, and LVMI), large left atrium (≥50 mm), and plasma levels of NT-proBNP. After adjusting for other variables, LVMI was independently associated with both elevated cTnI and serum cTnI levels, suggesting that LVMI was the major
Disclosures
The authors have no conflicts of interest to disclose.
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Clinical utility of natriuretic peptides and troponins in hypertrophic cardiomyopathy
2016, International Journal of CardiologyCitation Excerpt :Increased left atrial size, a marker of chronic diastolic dysfunction, correlates with natriuretic peptide levels in HCM. Table 1a displays eleven studies showing moderately strong associations between natriuretic peptides and left atrial size (r-values ranging from 0.21 to 0.45) [7,9,29,30,33–38]. Patients with elevated BNP ≥ 200 pg/mL in one study were shown to have larger left atria (mean difference in diameter 5.1 mm) [23].
Circulating Biomarkers in Hypertrophic Cardiomyopathy
2022, Journal of the American Heart AssociationSignificance and Determinants of Plasma Apelin in Patients With Obstructive Hypertrophic Cardiomyopathy
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