Coronary Artery DiseaseImpact of Percutaneous Coronary Intervention on Exercise-Induced Repolarization Changes in Patients With Stable Coronary Artery Disease
Section snippets
Methods
The study enrolled consecutive patients who were scheduled to undergo coronary angiography according to guidelines for the diagnosis and management of patients with stable ischemic heart disease.9 Because of the impact of gender on arrhythmogenesis, all included subject were men.10 They were aged >18 years, exhibited sinus cardiac rhythm, and were able to perform treadmill exercise stress testing according to the Bruce protocol. The exclusion criteria were history of myocardial infarction,
Results
The 2 groups did not differ significantly in demographic and clinical characteristics (Table 1). In the interventional group, there were 9 patients (45%) with culprit stenosis on LAD, 7 (35%) with culprit stenosis on RCA, and 4 (20%) patients with culprit stenosis on CxA. The average percentage of culprit stenosis was 89 ± 5% (LAD 91 ± 3%; RCA 86 ± 5%; CxA 92 ± 4%). Syntax score in the interventional group was 7.2 ± 3.
We found no differences in the exercise stress parameters (values of baseline
Discussion
In the present study, we found that in patients with significant coronary artery stenosis, the novel ECG indexes of cardiac arrhythmogenic risk, assessed at peak exercise during exercise stress testing, change from baseline in the opposite direction compared to patients without clinically significant coronary artery lesions. This change, however, becomes the same as in the control group on the successful PCI procedure.
In a recent study, Korantzopoulos et al8 observed similar differences in the
Disclosures
The authors have no conflicts of interest to disclose.
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T-Wave Indices and Atherosclerosis
2018, Current Atherosclerosis Reports
This work was supported by Croatian Science Foundation (grants no. 02.05/48 and 3718).
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