Poster session IV
686: Perinatal outcomes in infants with congenitally and postnatally acquired cytomegalovirus infection

https://doi.org/10.1016/j.ajog.2014.10.892Get rights and content

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Objective

Perinatal cytomegalovirus (CMV) infection affects an estimated 40,000 newborns annually. Better understanding of effects of CMV infection on perinatal outcomes may be useful in prenatal management of congenital cases. We compared obstetric characteristics in infants with congenital and postnatal CMV infection.

Study Design

We conducted a retrospective study at a university medical center from January 1, 2001 to December 31, 2010 to identify all infants <100 days old diagnosed with congenital and postnatal CMV infection. Infants were tested by rapid shell vial and routine viral cultures. Congenital infection was defined as infants < 28 days old whose urine tested positive for CMV, while postnatal infection was defined as infants 29-99 days old whose urine tested CMV positive. Descriptive statistics were performed.

Results

A total of 48 out of 974 (4.9%) tested infants were diagnosed with CMV infection [14 (29.2%) congenital and 34 (70.8%) postnatal] per urine viral studies. One subject did not have available medical data for review. There was a high rate of preterm birth (PTB) in both groups: 8/14 (57%) of congenitally infected infants and 19/33 (58%) of postnatally infected infants had been born at <37 weeks. The rate of spontaneous PTB in the congenital CMV group was 4/14 (28.6%). Furthermore, 4/8 (50%)

Conclusion

Our findings suggest that CMV infection may be a risk factor for PTB, as some other studies have reported. Although the finding of increased PTB is expected in the postnatal cohort given that preterm infants are more at risk for acquiring CMV infection, our finding that infants with congenital CMV infection had higher rate of spontaneous PTB than baseline is unexpected. Further large-scale studies are needed to evaluate the role of CMV congenital infection in spontaneous PTB.

Obstetric/delivery

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