ResearchObstetricsAssociation between maternal characteristics, abnormal serum aneuploidy analytes, and placental abruption
Section snippets
Materials and Methods
The study sample was drawn from a cohort of 236,714 singleton pregnancies undergoing first- and second-trimester prenatal serum screening through the California Prenatal Screening Program administered by the Genetic Disease Screening Program (GDSP), with expected dates of delivery in 2009 and 2010. The sample was restricted to pregnancies that had a linked live birth and hospital discharge record in the birth cohort database maintained by the Office of Statewide Health Planning and Development
Results
When analyzing the demographics of the cohort, Asian race (OR, 1.4; 95% CI, 1.1–1.7) and maternal age older than 34 years (OR, 1.4; 95% CI, 1.2–1.6) were more common among women with placental abruption. Women with placental abruption were also more likely to have 1 or more hypertensive disorders. Specifically, they were more than twice as likely to have pregestational hypertension (OR, 2.5; 95% CI, 1.6–3.8) and more than 3 times as likely to have preeclampsia or eclampsia (OR, 3.8; 95% CI,
Comment
In this large population-based study, we show that abnormal aneuploidy screening analytes are independent markers of placental abruption, including among patients with hypertensive disease. Although the greatest risk for placental abruption was observed in the pregnancies with hypertensive disorders (nearly 3- to more than 5-fold increased risk), first-trimester PAPP-A of the fifth percentile or less and second-trimester AFP of the 95th percentile or greater were associated with an increased
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2021, Journal of Gynecology Obstetrics and Human ReproductionCitation Excerpt :Recently, the use of NLR and PLR has been studied in the field of obstetrics and was found to be associated with adverse pregnancy outcomes such as preeclampsia [15] and gestational diabetes mellitus (GDM) [16]. While other biomarkers have been suggested to provide predictive information regarding future PA [17–19], the use of NLR and PLR in the prediction of PA, to the best of our knowledge, has not yet been studied. We aimed to evaluate the feasibility of using the hematological indices NLR and PLR taken before 20th week of gestation as predictors of the occurrence of PA later in pregnancy.
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2019, Taiwanese Journal of Obstetrics and GynecologyCitation Excerpt :Because placental abruption could lead to serious obstetric morbidity and perinatal death (up to 12.9%) [54], early detection of placental abruption may improve pregnancy outcomes. Accordingly, measurement of maternal serum alpha-fetoprotein in the second-trimester [55,56], and mean platelet volume and platelet distribution width [57] as well as Doppler study at the 20th weeks of gestation [58], have been developed for early detection of placental abruption. As such, these methods may also be useful for the prediction of placental abruption during antenatal care of RIF patients.
Pre-pregnancy or first-trimester risk scoring to identify women at high risk of preterm birth
2018, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :Here, we developed and tested a pre-pregnancy or first-trimester cumulative risk scoring tool for preterm birth using beta-coefficients from multivariable models. Because preterm birth shares risk factors for other adverse maternal and infant outcomes [19–23], we also evaluated whether scores identified women with adverse outcomes who did not have preterm birth. Given racial and economic disparities in preterm birth, risk scores were evaluated overall and by racial/ethnic and payer subgroups [24,25].
96-Placental Abruption
2018, Obstetric Imaging: Fetal Diagnosis and Care: Second Edition
This study was supported in part by grants from the March of Dimes Prematurity Center, Stanford University School of Medicine, Stanford, CA.
The authors report no conflict of interest.
Cite this article as: Blumenfeld YJ, Baer RJ, Druzin ML, et al. Association between maternal characteristics, abnormal serum aneuploidy analytes, and placental abruption. Am J Obstet Gynecol 2014;211:144.e1-9.