American Journal of Orthodontics and Dentofacial Orthopedics
Original articleTiming of force application on buccal tooth movement into bone-grafted alveolar defects: A pilot study in dogs
Section snippets
Material and methods
This study was implemented and accomplished in accordance with regional Ethics Committee guidelines. The experimental protocol was approved by the Animal Experimental Ethical Committee of our hospital (HKDL[2019]502).
Six skeletally mature (1.5 years) male beagle dogs (15-16 kg) were included in the study. The surgical procedure was carried out under general anesthesia with atropine sulfate (0.04 mg/kg body weight, intramuscular [IM]), ketamine (2.5 mg/kg, IM), and a 4% solution of pentobarbital
Results
All sites showed uneventful healing without marked swelling or tissue damage after the surgical procedure.
During 6 weeks of active OF, the mean expansion of P2 was 2.42 mm in group F-0, which was significantly greater than that in group F-4 (1.25 mm) and group F-8 (1.62 mm). All groups had uncontrolled buccal tipping of the P2. The P2 tipped 9.03° ± 1.02°, 5.32° ± 2.19°, and 3.24° ± 1.27° in groups F-0, F-4, and F-8, respectively, with a significant difference between group F-0 and group F-4 (P
Discussion
As evident from the results of the present study, the null hypothesis was rejected. Compared with the other 2 groups, the group in which OF was applied 4 weeks after augmentation provided the best functional stimulation for the alveolar bone graft.
Radiography revealed no obvious repair of new bone 4 weeks after defect creation, indicating that the defect model in our study was stable. In addition, P2 was the most concave part of the buccal alveolar wall and was chosen for buccal tooth movement.
Conclusions
This report demonstrated that OF application at 4 weeks after an augmentation procedure could provide the best functional stimulation for an alveolar bone graft. This strategy promoted the degradation of bone substitutes and enhanced the formation of new bone.
Author CRediT Statement
Zhigui Ma and Zixiao Wang: conceptualization, methodology, writing—original draft preparation together; Jisi Zheng: investigation and data curation; Xinwei Chen and Weifeng Xu: visualization and resources; Duohong Zou: writing—reviewing; Shanyong Zhang and Chi Yang: supervision, writing—reviewing and editing.
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2022, AJO-DO Clinical CompanionTiming of orthodontic tooth movement in bone defects repaired with synthetic scaffolds: A scoping review of animal studies
2021, Archives of Oral BiologyCitation Excerpt :It was found that orthodontically-induced alveolar remodelling may allow earlier tooth movements into the grafted area (Araújo, Carmagnola, Berglundh, Thilander, & Lindhe, 2001a). Ma et al. (2021) reported that the rate of resorption of bone repair materials and new bone formation could be accelerated by optimum magnitude of orthodontic forces application in the direction of the grafted sites. Mechanical loading from OTM can stimulate pre-osteoblasts and mesenchymal cells to differentiate into osteoblasts.
Zhigui Ma and Zixiao Wang are joint first authors and contributed equally to this work.
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest, and none were reported.
This study was supported by the National Natural Science Foundation of China (81800932, 31870969, and 81870785), Shanghai Summit and Plateau Disciplines, Science and Technology Commission of Shanghai Municipality Science Research Project (14DZ2294300), Project of Outstanding Youth Backbone of the 9th Hospital (jyyq08201601), Shanghai Municipal Hospital Emerging Frontier Technology United Key Project (SHDC12017101), and Clinical Research Project of Multi-Disciplinary Team, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine (201913).