Original ArticlesEffect of Testing Frequency on the Time to Detect Glaucoma Progression With Optical Coherence Tomography (OCT) and OCT Angiography
Section snippets
PARTICIPANTS
This longitudinal study includes primary open angle glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study (DIGS)25,26 who underwent both OCT and OCTA testing. Institutional review board approval was obtained, and written informed consent was acquired from all participants. This study adhered to the tenets of the Declaration of Helsinki and was conducted in accordance with the Health Insurance Portability and Accountability Act.
Inclusion criteria include (1) diagnosis of
RESULTS
This study included 156 eyes of 98 patients with a mean (95% CI) baseline age of 68.6 (66.8, 70.4) years over a mean (95% CI) follow-up time of 3.5 (3.4, 3.6) years. A total of 21 eyes were excluded because of poor image quality. One-hundred twenty-seven eyes (81.4%) had early glaucoma at baseline with MD better than −6.0 dB, and 29 eyes (18.6%) had moderate to advanced VF loss (MD worse than −6 dB). The patients were seen over a mean (95% CI) of 5.3 (5.1, 5.5) visits. At the first visit, the
DISCUSSION
This study evaluated the time required to detect OCT and OCTA progression in glaucoma eyes using different rates of cpCD and cpRNFL loss with respect to various frequencies of testing per year. We also provided information on how frequently testing should be performed to detect different rates of loss. With a similar frequency of testing, cpCD detected progression slightly sooner than cpRNFL. cpRNFL and cpCD were comparable and complementary in detecting glaucoma progression over time. Two
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Supplemental Material available at AJO.com.
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Golnoush Mahmoudinezhad and Sasan Moghimi had equal contributions as co–first authors.