Original articleChoroidal Thickness in Normal Eyes Measured Using Cirrus HD Optical Coherence Tomography
Section snippets
Methods
A retrospective analysis was performed on 34 eyes of 34 normal patients, who underwent high-definition 1-line raster scanning at the New England Eye Center, Tufts Medical Center, Boston, Massachusetts, between November 23, 2009 and December 21, 2009. Medical chart review was done to identify patients with no retinal or choroidal pathology. Patients with a myopic refractive error of greater than −6.0 diopters were excluded from this study. Cirrus HD-OCT scans were obtained from patients as part
Results
The group of 34 subjects consisted of 17 men and 17 women, with an average age of 51.1 years (range, 22 to 78 years). Nine out of 34 were undilated volunteers. All eyes had normal foveal contour with no retinal pathology and no abnormalities of the choroid. The delineation between choroid and sclera could be visualized easily to permit reliable thickness measurements to be performed in 34 out of 46 (74%) of the images evaluated in this study. Of the 12 normal eyes in which choroidal thickness
Discussion
The choroid is a highly vascular tissue, necessitating in vivo imaging to accurately determine its true structure and thickness. Until recently, information regarding choroidal thickness in normal eyes was based primarily on histologic results, which do not necessarily reflect the true measurements of this dynamic tissue. OCT has been well established as an accurate imaging study of known retinal pathology through good correlation between histology of animals and humans in vivo;17 however,
Varsha Manjunath graduated with high honors with a Bachelor of Science degree from McGill University, Quebec, Canada, and is presently between her third and fourth year of medical school at Drexel University College of Medicine, Philadelphia, Pennsylvania. She was awarded the of the Research to Prevent Blindness Medical Student Eye Research Fellowship in 2009, and is currently involved in a one-year research fellowship at the New England Eye Center investigating retinal diseases using prototype
References (18)
- et al.
Enhanced depth imaging spectral-domain optical coherence tomography
Am J Ophthalmol
(2008) - et al.
A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes
Am J Ophthalmol
(2009) - et al.
Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes
Am J Ophthalmol
(2009) Age-related choroidal atrophy
Am J Ophthalmol
(2009)- et al.
Histologic correlation of in vivo optical coherence tomography images of the human retina
Am J Ophthalmol
(2006) - et al.
Ultrahigh resolution optical coherence tomography of the monkey foveaIdentification of retinal sublayers by correlation with semithin histology sections
Exp Eye Res
(2004) - et al.
Optical coherence tomography
Science
(1991) - et al.
Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy
Retina
(2009) Enhanced depth imaging optical coherence tomography of retinal pigment epithelial detachment in age-related macular degeneration
Am J Ophthalmol
(2009)
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Varsha Manjunath graduated with high honors with a Bachelor of Science degree from McGill University, Quebec, Canada, and is presently between her third and fourth year of medical school at Drexel University College of Medicine, Philadelphia, Pennsylvania. She was awarded the of the Research to Prevent Blindness Medical Student Eye Research Fellowship in 2009, and is currently involved in a one-year research fellowship at the New England Eye Center investigating retinal diseases using prototype and commercial optical coherence tomography devices.