Trial DesignAcute decompensated heart failure syndromes (ATTEND) registry. A prospective observational multicenter cohort study: Rationale, design, and preliminary data
Section snippets
Study design
The acute decompensated heart failure syndromes (ATTEND) registry is a prospective observational multicenter cohort study that is currently underway in Japan. Patients are enrolled at the first admission and then followed up; thus, data collection is patient based and not event based.
Study objectives
The objectives of the ATTEND registry are to clarify the overall clinical characteristics of patients with AHFS, including (1) demographic characteristics and clinical profile, (2) current treatments, (3)
Clinical profile of AHFS in the present study and comparison to those of Western studies
As of May 18, 2009, a total of 1,110 patients had been enrolled at 29 hospitals. The characteristics of these patients are shown in Table I. The mean age was 73 ± 14 years and 58.9% were men. The percentage of patients with a history of hospitalization for heart failure was lower than that of patients with de novo heart failure (37.4% vs 62.6%). Hypertension was the most common risk factor (70.6%). The underlying diseases that led to AHFS were ischemic heart disease in 33.2%, hypertensive heart
Discussion
To the best of our knowledge, the ATTEND registry is the first epidemiological study of AHFS in the Asia Pacific region. It has provided detailed data on the baseline characteristics and profile of Japanese patients with AHFS (except those with ACS) and has revealed several important differences compared with patients with AHFS in Western countries. The present study not only investigated patient characteristics but also the hemodynamic profile of patients with AHFS. Regarding the etiology of
Acknowledgements
We thank Dr Mihai Gheorghiade for his critical review of our article. We also thank all investigators for their contributions.
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See Appendix online for complete listing of the ATTEND Investigators.