Mini reviewVasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7
Section snippets
Vasculogenic mimicry—Discovery and characteristics
It is well known that the supply of oxygen and nutrients via connection to the blood circulation system is an essential factor in tumor growth and metastasis (Hanahan and Weinberg, 2011, Hanahan and Weinberg, 2000). In addition to tumor angiogenesis, aggressive tumor cells may possess another independent mechanism for generating blood supply called vasculogenic mimicry (VM) (Folberg and Maniotis, 2004, Maniotis et al., 1999). VM describes the ability of aggressive cancer cells to form
Function and mechanism of effector caspases in VM
The class of effector caspases consists of caspase-3, -6 and -7, which are all known to play a crucial role in apoptosis (Jiaqi and Juan, 2002, Porter and Jänicke, 1999). In contrast, several researchers have revealed non-apoptotic functions, including proliferation, migration, and differentiation in normal tissues as well as in tumor cells (Shalini et al., 2014). A study by Ishizaki et al. (1998), for example, demonstrated a connection between caspase-3 activity and the enucleation of
Conclusion
In this paper we have summarized the possible role of effector caspase-3, caspase-6 and caspase-7 in the formation of vessel-like, ECM-rich structures of aggressive tumor cells. We have additionally reviewed different mechanisms by which these caspases may contribute to VM. The summary of our investigation is that caspase-3, caspase-6 and caspase-7 may exercise an important function in tumorigenesis, particular in vasculogenic mimicry. However, at present, only the connection of caspase-3 to VM
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