Chapter 47 - Miscellaneous Drugs, Materials, Medical Devices and Techniques
Section snippets
Aluminum (SEDA-36, 726)
Aluminum (Al) is a trivalent cation found in most animal and plant tissues and natural waters. Human beings are naturally exposed to Al in varying quantities in their daily lives from food, water and air. Even though there exists no formal characterization of health hazards, use of Al in numerous cosmetics such as antiperspirants, sunscreens and lipsticks, over the counter pharmaceuticals, injected vaccines that contain adjuvant Al as well as exposure in industrial settings may be a potential
Tumorigenicity
Al salts mainly Al-chlorhydrate (ACH) is an excipient widely used in underarm deodorant/antiperspirants that block sweat ducts upon application when it converts to insoluble Al-hydroxide. Recent in vitro studies using the MCF-7 breast cancer cell line by Iskakova for the first time alludes to the possible role of Al in breast cancer [4E]. Their studies show that Al-chlorhydrate can increase the migratory and invasive properties of breast cancer cells following long-term exposure (32 weeks).
Nervous System
Benzyl alcohol is an aqueous soluble preservative widely used in injectable pharmaceutical preparations as well as in cosmetic products. Although toxic in neonates and infants, it is generally recognized as safe by the FDA at concentrations up to 5% in adults. The effect of benzyl alcohol present as preservative in bacteriostatic normal saline has recently come under investigation when administered via intraarticular injection. Patients who undergo MRI-based arthrography for standard clinical
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Taxol((R))-induced phosphatidylserine exposure and microvesicle formation in red blood cells is mediated by its vehicle Cremophor((R)) EL
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Vitamin D intoxication in two brothers: be careful with dietary supplements
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Vitamin D supplementation and risk of toxicity in pediatrics: a review of current literature
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Over-supplementation of vitamin D in two patients with primary hyperparathyroidism
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Lomustine's nanoemulsion as nose-to-brain drug delivery system for CNS tumor treatment
2023, Saudi Pharmaceutical JournalDark and photoinduced cytotoxicity of solubilized hydrophobic octa-and hexadecachloro-substituted lutetium(III) phthalocyanines
2022, Journal of Photochemistry and Photobiology A: ChemistryCitation Excerpt :The application of Cremophor EL in drug delivery induces a serious number of side effects that restrict its utilization. For instance, its use has been associated with severe anaphylactoid hypersensitivity reactions, hyperlipidemia, abnormal lipoprotein patterns, aggregation of erythrocytes, and peripheral neuropathy.[19] Nowadays the polymer micelles based on biocompatible and biodegradable polylactide look promising for the delivery of bioactive substances.[20,21]
Pharmacokinetic behaviors of soft nanoparticulate formulations of chemotherapeutics
2023, Wiley Interdisciplinary Reviews: Nanomedicine and NanobiotechnologyPossible effects of excipients used in the parenteral drugs administered in critically ill adults, children, and neonates
2020, Expert Opinion on Drug Safety