Drug Delivery Devices and Therapeutic Systems

Drug Delivery Devices and Therapeutic Systems

Developments in Biomedical Engineering and Bioelectronics
2021, Pages 367-394
Drug Delivery Devices and Therapeutic Systems

Chapter 18 - Dissolvable-soluble or biodegradable polymers

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Abstract

“Polymers” are monomer-derived basic chemical entities that have leveraged immense opportunities for several clinical/therapeutic applications. Since the last decade, “Biodegradable polymers,” a special category of polymers, have gained special attention from the scientific community, especially for prosthetic/medical/biomedical applications. From a medical/biomedical perspective, the terms “biodegradable/bioresorbable/bioabsorbable/dissolvable-soluble polymers” encompass various classes of polymers that get degraded by enzymatic/nonenzymatic means to bioinert and biocompatible by-products and are excreted thereafter, thus obviating the need for surgical interventions. While from the environmental perspective, a biodegradable polymer is the one that gets degraded/decomposed by microbial (bacterial/fungal/algal) metabolism to eco-friendly by-products like gases (CO2, N2), water, biomass, and inorganic salts. Realization of the immense applicability of this category of polymers has conferred them to a status of “materials of today.” This chapter discusses in brief the history, classification, and types of biodegradable polymers, mechanisms of biodegradation, novel biopolymeric-based systems, as well as advancements in their processing and evaluation methods. Also, medical, biomedical, pharmaceutical, and packaging applications of various biopolymers, and their present and future scenario from commercial as well as regulatory viewpoints have been focused upon.

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