Kidney Biomarkers

Kidney Biomarkers

Clinical Aspects and Laboratory Determination
2020, Pages 19-153
Kidney Biomarkers

Chapter 2 - Utility of the “omics” in kidney disease: Methods of analysis, sampling considerations, and technical approaches in renal biomarkers

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Abstract

Over the last decade, there has been a considerable progress in the discovery and development of novel biomarkers of kidney disease. All of this has been successfully achieved due to the appearance of systems biology that has brought forward the concept of “omics” technologies (i.e., genomics, transcriptomics, proteomics, and metabolomics), which have evolved to become a major component and scientific approach in the analysis of biological systems. This has also allowed a better understanding of the molecular pathogenesis in a variety of renal disorders. Hence, in this chapter, we will summarize the “omics” profiling approaches as well as their role in the discovery of new biomarkers of kidney diseases that might provide guidance for clinical decision making and targeted therapy in individual patients. We will also discuss the integrating role of bioinformatics and the need for standardized procedures for sample preservation, statistical analysis, and reporting of results.

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