Influence of Drug Properties and Routes of Drug Administration on the Design of Controlled Release System

doi:10.1016/B978-0-12-814423-7.00006-X

Dosage Form Design Considerations

Volume i

Advances in Pharmaceutical Product Development and Research

2018, Pages 179-223

https://doi.org/10.1016/B978-0-12-814423-7.00006-X Get rights and content

Abstract

To achieve therapeutic drug concentration is not a major task, rather maintaining that concentration for the desired period is clinically more important and is a demanding area of drug delivery science. However, the design of controlled release formulations requires many factors to be considered such as drug delivery rate, delivery duration, physicochemical properties of the drug, nature of excipients, the route of administration, and the dosing interval etc. The objective of the chapter is to provide a complete understanding of several physicochemical properties of the drug that ultimately influence the performance of drug molecule. The chapter includes various aspects of designing controlled release formulations which includes rationale of design, drug properties (molecular weight, pH, pK_a, etc.), pharmacokinetic aspects (absorption, distribution, etc.), pharmacodynamic aspects (dosing interval/frequency, patient condition, etc.), and route of drug administration (oral, transdermal, parenteral, etc.).

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Chapter 6 - Influence of Drug Properties and Routes of Drug Administration on the Design of Controlled Release System

Abstract