Chapter 12 - Toxicological Hazard Analysis of Nanomaterials With Potential for Utilization in Consumer Goods
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Unmodified single nanoparticles undergo a motion-pattern transition on the plasma membrane before cellular uptake
2021, Nano TodayCitation Excerpt :Many studies have been performed on specific interactions of NPs with particular modifications based on ligand-receptor pairing [10–13]. On the other hand, our knowledge on the environmental NPs are very limited, and most of concerns on nanotoxicity come from the unknown or “unmodified” NPs non-specifically landing onto the cell surface [4]. Importantly, the unmodified NPs would acquire biomolecules to form protein corona in the biological environment before reaching the cell and, if their size is appropriate (usually in a range of 50–100 nm), can subsequently enter the cells mediated by membrane receptors, leading to potential cytotoxicity [14–18].
Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting
2019, Journal of Medicinal Chemistry
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