Obesity

Obesity

Oxidative Stress and Dietary Antioxidants
2018, Pages 1-15
Obesity

Chapter 1 - Oxidative Stress and Inflammation in Obesity and Metabolic Syndrome

https://doi.org/10.1016/B978-0-12-812504-5.00001-5Get rights and content

Abstract

Obesity is a worldwide public health problem that has been increasing in the last decades. It is characterized by excessive fat accumulation, and accompanied by low-grade chronic inflammation and increased oxidative stress. A growing body of evidence supports that both chronic inflammation and oxidative stress play a key role in the development of obesity-associated comorbidities such as insulin resistance (IR), which probably is the first step of a dysfunctional metabolic system. Subsequent to central obesity, IR, hyperglycemia, hypertriglyceridemia, hypoalphalipoproteinemia, hypertension, and fatty liver are grouped in the so-called metabolic syndrome (MetS). The purpose of this chapter is to review the clinical correlates of systemic oxidative stress and inflammation markers in patients with obesity or MetS.

References (0)

Cited by (19)

  • Mesenchymal stem cell therapy attenuates complement C3 deposition and improves the delicate equilibrium between angiogenic and anti-angiogenic factors in abortion-prone mice

    2022, Molecular Immunology
    Citation Excerpt :

    Compared to normal pregnant women, it is reported that obese pregnant women express significantly higher levels of adipsin and ASP in the placenta. Likewise, preeclamptic women also exhibit significantly elevated adipsin levels in the serum in late pregnancy (Poveda et al., 2016; Ruiz-Ojeda et al., 2018; Sivakumar et al., 2013). On the other hand, complement component receptor 1-like protein (Cr1l/Crry) shields autologous murine cells from complement-mediated injury at the feto-maternal unit by suppressing both the classical and alternative pathways of complement activation.

  • Prosopis alba mesocarp flour: A source of functional ingredients

    2021, Prosopis as a Heat Tolerant Nitrogen Fixing Desert Food Legume: Prospects for Economic Development in Arid Lands
View all citing articles on Scopus
View full text