Chapter 6 - Chelating Therapy in Metal Storage Diseases

https://doi.org/10.1016/B978-0-12-803072-1.00006-7Get rights and content

Abstract

Metal storage diseases include Wilson’s disease with copper deposition in liver, brain, and other organs, as well as other neurodegenerative diseases characterized by localized deposits of iron. Some chronic anemias requiring frequent blood transfusions may be associated with siderosis with pathological deposition of iron in several organs, including liver and heart. Thalassemia and sickle cell anemia are examples of such anemias affecting hundreds of thousands of individuals worldwide. Orally administered chelating agents, such as D-penicillamine or triethylene tetramine to mobilize copper, and deferiprone and/or deferasirox to mobilize iron, are life-saving agents in these serious conditions.

References (0)

View full text