Elsevier

Pathobiology of Human Disease

A Dynamic Encyclopedia of Disease Mechanisms
2014, Pages 722-740
Pathobiology of Human Disease

Pathophysiology of the Skin and Oral Squamous Mucosa in Allogeneic Hematopoietic Stem Cell Transplantation

https://doi.org/10.1016/B978-0-12-386456-7.02213-9Get rights and content

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for patients with malignant and nonmalignant diseases. Despite considerable progress in many areas, graft-versus-host disease (GVHD) continues to be a serious cause of morbidity and mortality after allogeneic HSCT. Advances in the understanding of GVHD pathogenesis have contributed to standardized measures to reduce risk, as well as improvements in management and outcomes. This article outlines the evolution of allogeneic HSCT in the context of selected scientific and clinical studies, with an emphasis on the pathophysiology of the salient manifestations of its major complication, GVHD, in the skin and oral cavity.

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Ana Carolina F. Motta is a professor of oral medicine at the Dental School of Ribeirao Preto, University of Sao Paulo; Researcher fellow in the Division of Oral Medicine and Dentistry, Brigham and Women's Hospital.

Motta earned her DDS from the Dental School of the Federal University of Bahia and subsequently completed her oral medicine master and doctoral training at the University of Sao Paulo. She is assistant professor in oral medicine at the Dental School of Ribeirao Preto, University of Sao Paulo, and has special interest in oral mucosal diseases, dental care for special needs patients, and physiopathology of infectious diseases. She is a research collaborator at the Medical School of Ribeirao Preto and Ribeirao Preto Clinical Hospital. Currently, Motta is a research fellow at Brigham and Women's Hospital studying the pathophysiology of the oral chronic graft-versus-host disease.

Nathaniel S. Treister is an associate surgeon, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital; Oral medicine residency program director, Brigham and Women's Hospital and Harvard School of Dental Medicine; Assistant professor of oral medicine, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine.

Treister earned his DMD from the University of Pennsylvania School of Dental Medicine and subsequently completed his oral medicine certificate and oral biology doctoral training at the Harvard School of Dental Medicine. He is board certified in oral medicine and practices at Brigham and Women's Hospital and Dana-Farber Cancer Institute, with special interest in oral mucosal diseases, salivary gland diseases, and oral complications in cancer patients. He is an assistant professor of oral medicine in the Department of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine, where he is the program director of postgraduate oral medicine. He has published extensively in the field of oral medicine and is the coauthor of two clinical handbooks. He currently serves as study chair for Children's Oncology Group study ACCL1031 entitled “A Randomized Double Blinded Trial of Topical Caphosol to Prevent Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation.”

George F. Murphy is a professor of pathology, Harvard Medical School and Director, Program in Dermatopathology, Brigham and Women's Hospital. Murphy earned his MD from the University of Vermont and subsequently received a residency and fellowship training at the Massachusetts General Hospital in anatomic pathology and dermatopathology, respectively. Murphy is the director of the Brigham and Women's Hospital Dermatopathology Program and he has focused his career on the development of the discipline of academic dermatopathology. As such, he has been involved in the initiation and development of programs for diagnostic, research, and educational excellence in this subspecialty. Murphy supervises several research projects and collaborations, and he has hundreds of publications to his name. The current focus of Murphy's research is melanoma stem cell biology. He is also interested in elucidation of the cellular and molecular mechanisms responsible for cutaneous graft-versus-host disease subsequent to allogeneic stem cell transplantation, in an animal model. In addition, a major collaboration involving Brigham plastic and reconstructive surgery and the MIT Biomaterials Department focuses on tissue stem cell biology and cutaneous regenerative medicine. Cultivation of interdepartmental and interinstitutional interactions with the Dermatopathology Program have served as a paradigm for how academic dermatopathology may catalyze and synergize with disciplines as diverse as immunology, regenerative medicine, neurobiology, and stem cell science.

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