Progress in research on the effects of traditional Chinese medicine on the tumor microenvironment

doi:10.1016/S2095-4964(17)60345-5

Journal of Integrative Medicine

Volume 15, Issue 4, July 2017, Pages 282-287

https://doi.org/10.1016/S2095-4964(17)60345-5 Get rights and content

Abstract

Tumor microenvironment (TME) has received more and more attention as modern medical research has begun to understand its importance in tumorigenesis. The occurrence, development, metastasis and drug resistance of tumors are closely related to TME. TME is a complicated system, including nontumor cells, their secreted cytokines, extracellular matrix, among other components. The concepts of wholism and multitarget regulation in traditional Chinese medicine (TCM) make it well suited to the regulation of TME. In this paper, the authors reviewed the progress of TME research and the effect of TCM on TME, providing some views of Chinese medicine in antitumor research.

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According to network pharmacology and mRNA microarray chip analysis, JR may potentially act on hypoxia and inhibit the Wnt/β-catenin pathway. In vitro and in vivo experiments showed that JR significantly decreased hypoxia, and suppressed HCC cell features of proliferation, migration and invasion; furthermore, the hypoxia-induced increases in EMT and stemness marker expression in HCC cells were inhibited by JR. Results based on the co-administration of JR and an agonist (LiCl) or inhibitor (IWR-1-endo) verified that JR suppressed HCC cancer stem-like properties under hypoxia by blocking the Wnt/β-catenin pathway.
JR exerts potent anti-HCC effects by inhibiting cancer stemness via abating the Wnt/β-catenin pathway under hypoxic conditions.
Please cite this article as: Guo BJ, Ruan Y, Wang YJ, Xiao CL, Zhong ZP, Cheng BB, Du J, Li B, Gu W, Yin ZF. Jiedu Recipe, a compound Chinese herbal medicine, inhibits cancer stemness in hepatocellular carcinoma via Wnt/β-catenin pathway under hypoxia. J Integr Med. 2023; 21(5): 474–486.
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Citation Excerpt :
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Citation Excerpt :
It is well accepted that TCM can reduce the toxicity of chemotherapy and radiotherapy, enhance the antitumor effect of these therapies, alleviate tumor-induced clinical symptoms, and prolong the survival time of advanced-stage cancer patients [12]. Though the exact mechanism of TCM is not very clear, increasing data has shown that it may relate with regulation of tumor immune environment, the novel target according to the theory of “immune-reediting” [13,14]. Our previous work indicated that cinnamon extract was effective for leukemia treatment [15].
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ReviewProgress in research on the effects of traditional Chinese medicine on the tumor microenvironment

Abstract

J Integr Med

J Integr Med

Dev Cell

Cell

Immunity

Trends Immunol

Blood

Cancer Cell

Trends Cell Biol

J Proteomics

Biochim Biophys Acta

J Ethnopharmacol

Therapy-induced microenvironmental changes in cancer

J Mol Med (Berl)

The distribution of secondary growths in cancer of the breast. 1889

Cancer Metastasis Rev

Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding

Cancer Sci

High endothelial venules and lymphatic vessels in tertiary lymphoid organs: characteristics, functions, and regulation

Front Immunol

Diverse macrophages polarization in tumor microenvironment

Arch Pharm Res

Macrophage heterogeneity in tissues: phenotypic diversity and functions

Immunol Rev

Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasion in vitro

Br J Cancer

Tumor-derived factors modulating dendritic cell function

Cancer Immunol Immunother

Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment

Cancer Res

Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β

Eur J Immunol

Regulatory T cells in the tumor microenvironment and cancer progression: role and therapeutic targeting

Vaccines (Basel)

Review
Progress in research on the effects of traditional Chinese medicine on the tumor microenvironment