Review
Recent progress on anti-Candida natural products

https://doi.org/10.1016/S1875-5364(21)60057-2Get rights and content

Abstract

Candida is an intractable life-threatening pathogen. Candida infection is extremely difficult to eradicate, and thus is the major cause of morbidity and mortality in immunocompromised individuals. Morevover, the rapid spread of drug-resistant fungi has led to significant decreases in the therapeutic effects of clinical drugs. New anti-Candida agents are urgently needed to solve the complicated medical problem. Natural products with intricate structures have attracted great attention of researchers who make every endeavor to discover leading compounds for antifungal agents. Their novel mechanisms and diverse modes of action expand the variety of fungistatic agents and reduce the emergence of drug resistance. In recent decades, considerable effort has been devoted to finding unique antifungal agents from nature and revealing their unusual mechanisms, which results in important progress on the development of new antifungals, such as the novel cell wall inhibitors YW3548 and SCY-078 which are being tested in clinical trials. This review will present a brief summary on the landscape of anti-Candida natural products within the last decade. We will also discuss in-depth the research progress on diverse natural fungistatic agents along with their novel mechanisms.

Section snippets

Prof. YANG Ming-Hua obtained his Ph.D. degree in Science of Chinese Materia Medica from China Pharmaceutical University in 2010, and has been working there as a full professor (2020) and doctoral supervisor (2016). His researches cover the fields of chemistry of Chinese Materia Medica and the chemistry of natural medicinal products, with most research work done in antifungal components from Traditional Chinese Medicines (TCMs) and fungal metabolites. Dr. YANG has been the director for many

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    Prof. YANG Ming-Hua obtained his Ph.D. degree in Science of Chinese Materia Medica from China Pharmaceutical University in 2010, and has been working there as a full professor (2020) and doctoral supervisor (2016). His researches cover the fields of chemistry of Chinese Materia Medica and the chemistry of natural medicinal products, with most research work done in antifungal components from Traditional Chinese Medicines (TCMs) and fungal metabolites. Dr. YANG has been the director for many research projects at the state and ministerial/provincial levels, such as the National Natural Science Foundation of China. He has published more than 50 research papers in such well-known domestic and international journals, such as “Organic Letters”, “Journal of Natural Products”, “Organic Chemistry Frontiers”, and “Chemistry-A European Journal”. And he has been conferred serveal awards and honors academically, including the second prize of National Prize for Progress in Science and Technology (2015) and the first prize recipient of Jiangsu Provincial Science and Technology Awards (2013 and 2019)

    Available online 20 Aug., 2021

    [Research funding] This work was supported by the National Natural Science Foundation of China (No. 81773901), the Drug Innovation Major Project (Nos. 2018ZX09711-001-007 and 2018ZX09735002-003), and the 111 Project from Ministry of Education of China and the State Administration of Foreign Export Affairs of China (No. B18056)

    These authors have no conflict of interest to declare.

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