The polysaccharide isolated from Pleurotus nebrodensis (PN-S) shows immune-stimulating activity in RAW264.7 macrophages
Pleurotus nebrodensis polysaccharide (PN-S) can coordinate innate immunity with activating RAW264.7 macrophages.
References (21)
- et al.
Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived beta-glucans [J]
Blood
(2011) - et al.
Preparation and biological activities of chitosan from the larvae of housefly, Musca domestica [J]
Carbohyd Polym
(2008) - et al.
Purification, characterization and biological activity on hepatocytes of a polysaccharide from Flammulina velutipes mycelium [J]
Carbohyd Polym
(2007) - et al.
Structural features of immunologically active polysaccharides from Ganoderma lucidum [J]
Phytochemistry
(2002) The role of the macrophage in immune regulation [J]
Res Immunol
(1998)- et al.
T lymphocyte subpopulations and interleukin-2, interferon-c, and interleukin-4 in rat pulpitis experimentally induced by specific bacteria [J]
J Endodontics
(2002) - et al.
The role of nitric oxide (NO-) in the carcinogenic process [J]
Biochim Biophys Acta (BBA)–Rev Cancer
(1996) - et al.
Tumor necrosis factor-α and interferon-cmodulation of nitric oxide and allograft survival [J]
J Surg Res
(1995) - et al.
In vivo macrophage activation in chickens with acemannan, a complex carbohydrate extracted from Aloe vera [J]
Int J Immunopharmaco
(2000) - et al.
Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides [J]
Curr Microbiol
(2008)
Cited by (29)
Understanding immune-modulatory efficacy in vitro
2022, Chemico-Biological InteractionsCitation Excerpt :They are then fixed in 70% glacial ethanol, washed in PBS, resuspended in 1 ml of PBS containing 50 U/ml RNase and 50 μg/ml propidium iodide (PI) and then incubated in dark for 40 min at 4 °C. Cell cycle analysis is performed by flow cytometry and the population of cells in various phases are calculated [51]. After encountering stimuli, macrophages are induced to undergo morphodynamics such as increase in cell size, production of thin sheets of cell edges called filopodia (contains actin filaments) or lamellopodia (bears actin spikes) [21].
Bioactive components of mushrooms: Processing effects and health benefits
2021, Food Research InternationalImmunomodulatory activity of polysaccharide from Arca granosa Linnaeus via TLR4/MyD88/NFκB and TLR4/TRIF signaling pathways
2021, Journal of Functional FoodsClassification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus
2021, International Journal of Biological MacromoleculesCitation Excerpt :Most recently, Cui and colleagues demonstrated that the phagocytosis of macrophages was markedly improved after exposure to PN-S, with observed remarkable changes in morphology. PN-S was reported to improve RAW264.7 cells to progress via S and G2/M phases [196,197]. Additionally, PN-S could enhance the production of IL-6, NO, INF-γ, and TNF-α in the macrophages, with up-regulating mRNA expressions of IL-6, iNOS, INF-γ, and TNF-α being monitored in a dose-dependent manner.
Protective effect of Polygonatum sibiricum polysaccharide on cyclophosphamide-induced immunosuppression in chickens
2021, Research in Veterinary Science
Available online 20 May 2015
Research funding This work was supported by the National Natural Science Foundation of China (Nos. 31101357 and 31271915).
These authors have no conflict of interest to declare.