Lipid Nanocapsules: A Nanocarrier Suitable for Scale-Up Process
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Evidence of residual micellar structures in a lipid nanocapsule dispersion. A multi-technique approach
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2022, International Journal of PharmaceuticsCitation Excerpt :Therefore, compared with liposomes formulated by a process involving organic solvents and known to be unstable in biological fluids, LNC are more promising from an industrial perspective because they are prepared using a solvent-free, soft-energy procedure, and the excipients used are free of genetically modified organism and approved by the US Food and Drug Administration (FDA) (Hureaux et al., 2010). Furthermore, the industrial scale-up of LNC was previously investigated and an easy scalability of production was noted (Thomas and Lagarce, 2013). These features indicate that miR LNC have ample potential as candidates for industrial production and commercialization (Tsirimonaki et al., 2013).
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2021, International Journal of PharmaceuticsCitation Excerpt :Lipid nanocapsules (LNCs) are nanoparticles prepared by a solvent-free, low-energy phase inversion method (Hirsjärvi et al., 2013; Huynh et al., 2009; Thomas and Lagarce, 2013; Valcourt et al., 2016), and consist of an oily core composed of medium chain triglycerides which is enveloped by a layer of hydrophilic and hydrophobic surfactants (Heurtault et al., 2002; Mouzouvi et al., 2017; Valcourt et al., 2016).