Isolation and NMR Study on Swainsonine from Locoweed, Astragalus strictus
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Cited by (9)
Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines
2016, Bioorganic and Medicinal Chemistry LettersSimple indolizidine and quinolizidine alkaloids
2016, Alkaloids: Chemistry and BiologyCitation Excerpt :Swainsonine (378) could be obtained in gram quantities from extracts of A. lentiginosus by subjecting the basic aqueous fraction eluted from an ion-exchange column to continuous liquid–liquid extraction with dichloromethane, then purifying the alkaloid either by recrystallization from ammonia-saturated chloroform, by sublimation, or via a chloroform-soluble methylboronate derivative.208 Purification of swainsonine from the Tibetan species A. strictus by passage through D101 macroporous resin gave a sample of sufficient quality for thorough NMR spectroscopic analysis that included a full assignment of 13C signals,209 while ultrasound-assisted solvent extraction has been found to promote isolation and purification of the alkaloid from the Chinese locoweed O. ochrocephala.210 Detection of swainsonine in biological samples is also of interest; for example, a simple HPLC-UV method was reported for detecting the alkaloid in rat plasma.211
Water deficit induces swainsonine of some locoweed taxa, but with no swainsonine-growth trade-off
2012, Acta OecologicaCitation Excerpt :The evolutionary importance of locoweed SWA remains unclear, as it may not function as an anti-herbivore compound. Vertebrate livestock and wildlife consume locoweeds and subsequently suffer chronic damage and even death in the USA (Molyneux and Ralphs, 1992) as well as China, Tibet, and Mongolia (Zhao et al., 2009). Consistent with this observation is that high SWA var.
Determination of swainsonine in the endophytic Undifilum fungi by high-performance liquid chromatography with evaporative light-scattering detector
2012, ToxiconCitation Excerpt :Locoweed poisoning is the most widespread poisonous plant problem in China and the western United States, and causes great economic losses to the livestock industry (James and Panter, 1989; Li and Wang, 2003). The indolizidine alkaloid swainsonine (Fig. 1), which was first isolated from Swainnona canescens (Colegate et al., 1979) and subsequently from spotted locoweed, is the toxin responsible for inducing locoweed poisoning in animals (Molyneux and James, 1982; Ralphs et al., 2002; Zhao et al., 2009). In the past few years, a swainsonine-producing fungal endophyte, Undifilum oxytropis, previously annotated as Embellesia oxytropis, has been isolated from locoweeds (Braun et al., 2003; Yu et al., 2010).
First report of Erysiphe astragali causing powdery mildew on Astragalus strictus in Tibet, China
2023, Australasian Plant Pathology