Hepatobiliary & Pancreatic Diseases International
Review ArticleRole of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases
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Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis
2023, Biomedicine and PharmacotherapyLong noncoding RNA GAS5 inhibits LX-2 cells activation by suppressing NF-κB signalling through regulation of the miR-433–3p/TLR10 axis
2022, Digestive and Liver DiseaseCitation Excerpt :Col. I is another typical biomarker of not only liver fibrosis but also lung fibrosis [20,21]. A large number of studies have suggested that elevations in PCNA, MMP2, and MMP9 are also found in activated HSCs [22–24]. Therefore, we employed these 5 molecules as biomarkers representing liver fibrosis.
A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and balancing matrix metalloproteinases
2022, European Journal of PharmacologyCitation Excerpt :Matrix metalloproteinase -2 (MMP-2) expressions has been associated with many liver diseases such as liver fibrosis (Geervliet and Bansal, 2020). MMP-2 can promote fibrosis by increasing HSC proliferation in injured liver or by decreasing the capability for ECM remodeling (Kurzepa et al., 2014). HSC are considered the main source of the scar tissue during liver fibrosis and cirrhosis and their stimulation with TGF-β caused up-regulation of MMP-2 expression and activity (Hemmann et al., 2007).
Tissue inhibitor of metalloproteinases 1 is involved in ROS-mediated inflammation via regulating matrix metalloproteinase 1 expression in the sea cucumber Apostichopus japonicus
2022, Developmental and Comparative ImmunologyCitation Excerpt :TIMP1 is a prototypic inhibitor for most MMPs with a selective preference for binding to and inhibiting secretory-type MMPs (MMP1) in inflammation; however, it is a poor inhibitor of membrane-type MMPs (MT-MMPs). Increased MMP1 is a marker of cytokine-driven inflammation; it can degrade the extracellular matrix, promote cell dissociation and further affect the inflammatory cell chemotaxis through the expression of cytokines (Kurzepa et al., 2014). In sea cucumber, the elevation of AjMMP1 also suggests that it plays an important role in the occurrence of inflammation.
Pterostilbene is more efficacious than hydroxystilbenes in protecting liver fibrogenesis in a carbon tetracholride-induced rat model
2021, Journal of Functional Foods
Published online May 29, 2014.