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Updates in tuberculosis diagnosis in the USA

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  • Next-generation sequencing applications in clinical bacteriology

    2017, Biomolecular Detection and Quantification
    Citation Excerpt :

    With the progression of the sample in the clinical laboratory workflow, the involvement of the hands-on technician at each successive step is required, particularly where additional challenges are posed by particular organisms, some of which may be of critical public health importance. For example, Mycobacterium tuberculosis complex bacteria are extremely slow growing, taking weeks to 1–2 months to achieve susceptibility results, thus delaying appropriate treatment and potentially negatively impacting the patient outcome [10]. Furthermore, many aetiological agents, such as Borrelia burgdorferi (causative agent of Lyme disease), Bartonella species, Mycobacterium leprae, and HIV elude conventional testing altogether [11] (for an example, see the latest developments in HIV clinical treatment and surveillance using NGS reported by Metzner [12] and Berg et al. [13]).

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