Elsevier

Microbes and Infection

Volume 2, Issue 14, November 2000, Pages 1743-1756
Microbes and Infection

Review
Hepatitis C virus and interferon resistance

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Abstract

Interferon plays a critical role in the host's natural defense against viral infections and in their treatment. It is the only therapy for hepatitis C virus (HCV) infection; however, many virus isolates are resistant. Several HCV proteins have been shown to possess properties that enable the virus to evade the interferon-mediated cellular antiviral responses.

Keywords

interferon
hepatitis C virus
protein kinase
PKR

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