La pared celular de los hongos y el mecanismo de acción de la anidulafungina

doi:10.1016/S1130-1406(08)70024-X

Revista Iberoamericana de Micología

Volume 25, Issue 2, June 2008, Pages 78-82

https://doi.org/10.1016/S1130-1406(08)70024-X Get rights and content

Resumen

La pared celular de los hongos es una estructura con gran plasticidad que protege a la célula de diferentes tipos de estrés ambiental, entre los que destacan los cambios osmóticos. Además, la pared celular permite la interacción con el medio externo ya que algunas de sus proteínas son adhesinas y receptores. Algunos de sus componentes tienen una alta capacidad inmunogénica. La pared celular es una estructura característica de los hongos y está compuesta por glucanos, quitina y glicoproteínas. Al no estar presentes los componentes de la pared celular fúngica en el ser humano, esta estructura es una diana excelente para la terapia antifúngica. La anidulafungina, como el resto de las equinocandinas, actúa sobre la β-1,3-D-glucano sintetasa inhibiendo la formación del ß-1,3-D-glucano y produce, según el tipo de hongo, un efecto fungicida o fungistático.

Summary

The fungal cell wall is a structure with a high plasticity that protects the cell from different types of environmental stresses including changes in osmotic pressure. In adition to that, the cell wall allows the fungal cell to interact with its environment, since some of its proteins are adhesins and receptors. Some of its components are highly immunogenic. The structure of the fungal cell wall is unique to the fungi, and it is composed of glucan, chitin and glycoproteins. Since humans lack the components present in the cell walls of fungi, this estructure is an excellent target for the development of antifungal drugs. Anidulafungin, like the rest of echinocandins acts on ß-1,3-D-glucan synthase inhibiting the formation of ß-1,3-D-glucan and causing, depending on the type of fungus, a fungicidal or either a fungistatic effect.

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RevisiónLa pared celular de los hongos y el mecanismo de acción de la anidulafunginaThe fungal cell wall and the mechanism of action of anidulafungin

Resumen

Summary

Microbes Infect

Rev Iberoam Micol

Drug Resist Updat

Diagn Microbiol Infect Dis

Med Clin (Barc)

In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance

J Clin Microbiol

The glucan synthase complex of Aspergillus fumigatus

J Bacteriol

The structure and synthesis of the fungal cell wall

BioEssays

Fungicidal monoclonal antibody C7 binds to Candida albicans Als3

Infect Immun

Defining criteria for anti-mannan antibodies to protect against candidiasis

Curr Mol Med

Cell wall and secreted proteins of Candida albicans: identification, function, and expression

Microbiol Mol Biol Rev

Cell wall composition of the mycelial and blastospore forms of Candida albicans

J Gen Microbiol

The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of ß-1,3-D-glucan synthase

Proc Natl Acad Sci USA

Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-d-glucan synthase inhibitors

Antimicrob Agents Chemother

In vitro antifungal activities of anidulafungin and micafungin, licensed agents and the investigational triazole posaconazole as determined by NCCLS methods for 12,052 fungal isolates: review of the literature

Rev Iberoam Micol

Cell biology. A fungal Achilles’ heel

Science

Revisión
La pared celular de los hongos y el mecanismo de acción de la anidulafunginaThe fungal cell wall and the mechanism of action of anidulafungin