Technical ReportBiliary Imaging with Gd-EOB-DTPA: Is a 20-minute Delay Sufficient?☆
Section snippets
Materials and Methods
Sixteen patients (six men, 10 women; mean age, 63.5 years; range, 42–84 years) with known hepatic masses who were candidates for surgical resection were prospectively enrolled in an open-label study of Gd-EOB-DTPA (Eovist; Berlex, Montville, NJ) between November 1998 and January 2001. None of the patients had or were suspected of having biliary abnormalities. Informed consent was obtained from all participants by using a protocol approved by the Institutional Review Board.
Results
Contrast was identified within the biliary tree in all patients after contrast material administration on images obtained after a 20–minute delay (Figure 1, Figure 2).
The mean intrabiliary signal intensity (± standard deviation) before contrast material administration was 8 ± 7 in the common bile duct, 8 ± 8 in the right hepatic duct, and 7 ± 5 in the left hepatic duct. Twenty minutes after contrast material administration, the mean signal intensity (± standard deviation) was 92 ± 70 in the
Discussion
Previous studies performed in humans to evaluate hepatobiliary enhancement and excretion of Gd–EOB–DTPA showed rapid early enhancement of the liver, with enhancement peaking 20 minutes after injection (1). Hepatic signal intensity plateaus and then begins to decrease 90 minutes after injection. In rhesus monkeys, hepatic enhancement peaked 4 minutes after injection and then slowly declined (2). In both studies, the authors recommended a minimum delay of 20 minutes before liver imaging (1, 2).
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Biliary tract enhancement in gadoxetic acid-enhanced MRI correlates with liver function biomarkers
2016, European Journal of RadiologyCitation Excerpt :Second, in our study, HBP images were obtained at 15–18 min after an intravenous administration of gadoxetic acid. The biliary tract enhancement at 10–20 min after the administration of gadoxetic acid was enough in patients with normal liver function [26], on the other hand, the time to peak was longer than 30 min in patients with hepatic dysfunction. However, the differences between the signal intensities at 15 and 30 min were relatively small.
Diagnosis of biliary stone disease: T1-weighted magnetic resonance cholangiography with Gd-EOB-DTPA versus T2-weighted magnetic resonance cholangiography
2014, Clinical ImagingCitation Excerpt :Therefore, there is limitation in use of hepatocyte-specific contrast agent in hyperbilirubinemic patients [33]. Many studies demonstrated that the hepatobiliary phase images can be obtained 10 min after intravenous injection of Gd-EOB-DTPA in healthy patients and 20 min after in liver cirrhosis patients [16,20,34]. However, more delayed time is required to obtain optimal hepatobiliary phase images and Gd-EOB-DTPA-enhanced MRC in patients with decreased liver function [35,36].
Pediatric hepatobiliary magnetic resonance imaging
2013, Radiologic Clinics of North AmericaCitation Excerpt :Gadofosveset trisodium, a Food and Drug Administration–approved blood-pool gadolinium contrast agent for the assessment of aortoiliac disease in adults, may also be useful in pediatric vascular assessment (see Fig. 5). Finally, gadoxetate disodium (Gd-EOB-DTPA) is advantageous as an off-label use for biliary evaluation33–37 given the 50% hepatobiliary excretion in the setting of normal renal and hepatic function. Gd-EOB-DTPA provides a functional and anatomic MRCP examination (see Figs.4–6).
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Supported by a grant from Berlex.
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R.C.C. supported in part by the GE-AUR Radiology Research Academic Fellowship.