Chemistry & Biology
Volume 8, Issue 10, October 2001, Pages 981-995
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase1, 2
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Keywords
Enzyme specificity
Protein plasticity
Structure-based drug design
Thymidylate synthase
Abbreviations
TS, thymidylate synthase
EcTS, Escherichia coli TS
LcTS, Lactobacillus casei TS
hTS, human TS
DDT, N,O-didansyl-L-tyrosine
dUMP, 2′-deoxyuridine-5′-monophosphate
mTHF, 5,10-methylene-5,6,7,8-tetrahydrofolate
PABA, p-aminobenzoic acid
SAR, structure–activity relationship
Cited by (0)
- 1
Escherichia coli thymidylate synthase numbering is used unless otherwise noted.
- 2
PDB coordinates have been deposited with the RCSB with accession ID: 1JG0.
- 3
Also corresponding author.
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