Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages
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New derivatives with electron-withdrawing substituents at C-2 of 3-oxoolean-1-en-28-oic acid were synthesized. Among them, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) (6) showed strong inhibitory activity against production of NO induced by IFN-γ in mouse macrophages (IC50, 0.4 nM).
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