The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding
Synthesis of 4β-deoxy-phorbol-12,13-dibutyrate (5a) and its biological activities related to tumor promotion are reported.
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Acknowledgements
This work was supported by a Grant-in-Aid for Scientific Research (C) (2) (No. 11660109) and on Priority Areas (A) (2) (No. 12045241) from Ministry of Education, Science, Culture and Sports of Japan (for K.I.) and from Japan Society for the Promotion of Science for Young Scientists (Y.N.), and by grants (CA31841, CA31845) from the National Institutes of Health (P.A.W.).
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