Episulfide inhibitors of lipoxygenase
Epoxide and episulfide substrate mimics were synthesized as inhibitors of soybean lipoxygenase. Regio- and chemoselective enzyme inhibition was observed with 12, 13-episulfides (et, 1a. Inhibition by 1a occurred with reduction of the enzyme active site iron from Fe(III) to the inactive Fe(II) with 1a but not with 4a.
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As of 12 October 1992, S.W. Wright's address will be: Pfizer Central Research, Eastern Point Road, Groton, CT 06340, USA
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