Lentiviruses as gene transfer agents for delivery to non-dividing cells

https://doi.org/10.1016/S0958-1669(98)80029-3Get rights and content

Abstract

Lentiviral vectors are proving to be effective agents for the direct delivery and sustained expression of a transgene in several tissues, including brain, retina, muscle and liver. Significant progress was achieved in the biosafety of HIV-derived vectors by eliminating all the viral sequences non-essential for transduction. Other vectors have also been developed from non-primate lentiviruses.

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