Abstract
The 5-hydroxytryptamine1A (5-HT1A) receptor in the CA1 region of the hippocampus is linked through a G protein to an inwardly rectifying potassium conductance. Activation of the 5-HT1A receptor results in a membrane hyperpolarization and decrease neuronal firing rate. The hippocampus contains a high concentration of the mineralocorticoid (MR) and glucocorticoid (GR) corticosterone (CT) receptor subtypes. Some laboratories have reported that CT modulates 5-HT1A receptor binding density and mRNA levels in area CA1 of the hippocampus; however, others have reported no change. Previous electrophysiological studies have demonstrated that acute (1 to 4 hour) MR activation in slices from adrenalectomized (ADX) rats attenuates the 5-HT1A receptor-mediated hyperpolarization, while acute MR + GR or GR activation alone did not alter the 5-HT1A response. Our results confirm that the 5-HT1A response was attenuated 2 to 8 hours following MR activation. However, we found that GR activation alone decreased the potency, but not the maximal response to 5-HT. Chronic (2-week) treatment with basal levels of CT did not alter the 5-HT1A response. Administration of high concentrations of CT in vitro to neurons form chronically treated ADX rats decreased the magnitude of the 5-HT1A receptor-mediated hyperpolarization. We conclude that the 5-HT1A receptor-effector system in CA1 hippocampal pyramidal neurons is modulated by CT in a dose- and time-dependent manner.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Beck, S., Choi, K., List, T. et al. Corticosterone Alters 5-HT1A Receptor-Mediated Hyperpolarization in Area CA1 Hippocampal Pyramidal Neurons. Neuropsychopharmacol 14, 27–33 (1996). https://doi.org/10.1016/S0893-133X(96)80056-X
Published:
Issue Date:
DOI: https://doi.org/10.1016/S0893-133X(96)80056-X
Keywords
This article is cited by
-
Stress and the brain: from adaptation to disease
Nature Reviews Neuroscience (2005)
-
Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
Nature Neuroscience (2000)
-
Corticosteroids in the brain
Molecular Neurobiology (1998)