International Journal of Radiation Oncology*Biology*Physics
Issue Highlights
Section snippets
Keeping Our Finger on the Pulse: Reaffirming the Role of Radiation Therapy in the Curative Management of Early Stage Follicular Lymphoma
Campbell et al
The Lymphomas editorial team have taken a look at two recent high-profile studies that show radiation still has a role to play in the follicular lymphomas. With PET-staging there are some with early disease who may be cured by radiation alone. These cure rates may be further increased by the addition of systemic therapy. These studies reset the standard for the management of early follicular lymphoma.
Page 459
SBRT for Localized Prostate Cancer: Is it Ready for Take-Off?
Mitin et al
The GU editorial team have written an editorial to follow on from the recently published HYPO-RT-PC randomized trial of ultra-hypofractionated radiation in prostate cancer. This Swedish trial compared 7 fractions with 39, finding little difference in the cancer outcomes or the toxicity. The team concludes that there is enough here to support ultra-hypofractionation as a standard of care in prostate cancer but urge enrollment in 5 fraction SBRT trials.
Page 618
International Guideline on Dose Prioritization and Acceptance Criteria in Radiation Therapy Planning for Nasopharyngeal Carcinoma
Lee et al
A multinational group of radiation oncologists have come together to develop dose-guidelines for the treatment of nasopharyngeal carcinoma. They provide a practical reference for setting dose prioritization and acceptance criteria for tumor volumes and OARs.
Page 567
Fractionated and Acute Proton Radiation Show Differential Intestinal Tumorigenesis and DNA Damage and Repair Pathway Response in ApcMin/+ Mice
Suman et al
Although radiation is a known risk factor for cancer, the risk of cancer induction by protons is unknown. These authors used a mouse model for colorectal cancer and studied single dose and fractionated proton radiation to the gut. They quantitated pathways associated with tumorigenesis before and after exposure. They demonstrated increased gamma H2AX, 53BP1, and 8-oxo-dG, suggesting increased ongoing DNA damage with decreased DNA repair factors along with an increased proliferative
Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas
Göttgens et al
Human papillomavirus negative (HPV-ve) head and neck squamous cell carcinomas (HNSCC) have a poorer prognosis compared to those HPV+ve. Expression of p16 in HPV+ve HNSCC is thought to mediate radiosensitivity via inhibition of cyclin-dependent kinase (CDK) 4/6. These authors used the CDK4/CDK6 inhibitor, palbociclib, and assessed its effect on radiosensitivity. Only HPV-ve HNSCC cells were radiosensitized by palbociclib. Palbociclib led to a decreased induction of BRCA1 and RAD51
Fasting Reduces Intestinal Radiotoxicity, Enabling Dose-Escalated Radiation Therapy for Pancreatic Cancer
de la Cruz Bonilla et al
The use of curative doses of radiation in pancreatic cancer is constrained due to the close proximity of the duodenum to the head of the pancreas. These authors sought to determine if fasting protects the duodenum from high-dose radiation. Using a mouse model, they demonstrated that a 24 hour fast improved intestinal stem cell regeneration by microcolony assay and improved host survival from lethal doses of total abdominal radiation when compared to fed controls. Fasting
Podcast
The latest podcast by Anthony Zietman, MD, Editor in Chief of the International Journal of Radiation Oncology, Biology, Physics focuses on:
Follicular lymphomas/head and neck cancer