Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X

doi:10.1016/S0304-3940(02)00368-3

Neuroscience Letters

Volume 327, Issue 2, 19 July 2002, Pages 143-145

https://doi.org/10.1016/S0304-3940(02)00368-3 Get rights and content

Abstract

We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (P=0.04). Peak and Δ melatonin (peak–lowest melatonin) were found lower in patients with cardiac syndrome X (P=0.039 and P=0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients.

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^☆: This study was partly presented as an abstract at 4th International Congress on Coronary Artery Disease – from Prevention to Intervention, October 2001, Prague, Czech Republic.

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Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X☆

Abstract

Am. J. Cardiol.

Am. J. Cardiol.

Lancet

Increased P wave dispersion: a new parameter in patients with syndrome X

Can. J. Cardiol.

Chronic sympathetic activation affects dispersion of ventricular repolarization in syndrome X

Influences of melatonin administration on the circulation of women

Am. J. Physiol.