Elsevier

Nutrition Research

Volume 18, Issue 9, September 1998, Pages 1463-1468
Nutrition Research

Human study
Changes of oxidant and antioxidant status in humans due to H.Pylori infection

https://doi.org/10.1016/S0271-5317(98)00123-7Get rights and content

Abstract

Helicobacter pylori (H. pylori) infection has been found to generate many oxygen-centered free radicals which are capable of producing lipid peroxidation. Lipid peroxidation, on the other hand, induces deficiency of many important antioxidative micronutrients. Lipid peroxidations, in terms of TBARS (thiobarbituric acid reactions substances) were measured in a cohort of 10 adult male H. pylori infected human subjects before and after eradication of this bacterium by a triple therapy regimen using omeprazole (20 mg), amoxicillin (1g) and metronidazole (400 mg) twice a day for two weeks. Presence and absence of H. pylori were ascertained by the 13C urea breath test (UBT). Total radical antioxidant parameters (TRAP) reflecting the antioxidative protection were also measured. The TBARS (μmol/l) were reduced from 2.99 ± 0.61 to 1.16 ± 0.19 with concomitant increase of TRAP values (mmol/l) from 1.1 + 0.4 to 1.9 + 0.4. after eradication of H. pylori. These significant (P<0.001) changes of oxidant, i.e. lipid peroxidation, and antioxidant (TRAP) status suggest prevalence of oxidative stress in humans due to H. pylori infection. Since oxidative stress is implicated in many life threatening diseases, results of this preliminary study strongly suggest prospective investigations of the association of H. pylori with human health disorders.

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