Elsevier

Vaccine

Volume 19, Issues 25–26, 14 May 2001, Pages 3355-3359
Vaccine

Short communication
Rinderpest virus (RPV) ISCOM vaccine induces protection in cattle against virulent RPV challenge

https://doi.org/10.1016/S0264-410X(01)00069-XGet rights and content

Abstract

Rinderpest virus (RPV), a member of genus Morbillivirus in the family Paramyxoviridae, causes an acute and often fatal disease in cattle and other large ruminants. A subunit rinderpest vaccine consisting of an immune-stimulating complex (ISCOM) incorporating the RPV haemaggulutinin (H) protein, was examined for its ability to induce protective immunity in cattle, the natural host of RPV. All of four cattle vaccinated with the ISCOM vaccine survived challenge with virulent virus. Three were solidly protected, showing no clinical signs of infection, while the fourth animal developed only mild and transient symptoms. Virus neutralizing antibodies were produced at a significant level in all vaccinated cattle. These results indicate that this ISCOM vaccine is effective in producing protective immunity in cattle and should be a suitable means of delivering glycoprotein antigens from other morbilliviruses.

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Acknowledgements

We thank Dr S Ohkubo, Morinaga Milk Industry Co. Ltd., Japan for providing technical advice on the insect cell culture. This research was supported by a grant from the British Council and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan and Overseas Researcher Grant from Nihon University, Japan.

References (28)

  • L. Giavedoni et al.

    A vaccinia virus double recombinant expressing the F and H genes of rinderpest virus protects cattle against rinderpest and causes no pock lesions

    Proc. Natl. Acad. Sci. USA

    (1991)
  • K. Yamanouchi et al.

    Immunisation of cattle with recombinant vaccinia vector expressing the haemagglutinin gene of rinderpest virus

    Vet. Rec.

    (1993)
  • C.H. Romero et al.

    Protection of cattle against rinderpest and lumpy skin disease with a recombinant capripoxvirus expressing the fusion protein gene of rinderpest virus

    Vet. Rec.

    (1994)
  • L. Jones et al.

    Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus

    Vaccine

    (1991)
  • Cited by (12)

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    1

    Present address: Laboratory of Veterinary Microbiology, Nihon University, Fujisawa, Japan.

    2

    Present address: Otsuchi Marine Research Centre, Ocean Research Institute, University of Tokyo, Japan.

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