Trends in Neurosciences
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A simple model system for age-dependent DNA damage and cancer
2007, Mechanisms of Ageing and DevelopmentA switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation
2005, Molecular CellCitation Excerpt :Stress-induced mutation mechanisms differ from those that produce classical spontaneous mutations, which occur with a definable relationship to cell generations in proliferating cells (e.g., Lea and Coulson, [1949] and Luria and Delbrück, [1943]). The mechanisms underlying stress-induced genetic instability may provide improved models for the origins of genetic changes that promote aging (Finch and Goodman, 1997), evolution of resistance of pathogens to antibiotics and to host immune systems (Martinez and Baquero, 2000; McKenzie and Rosenberg, 2001), oncogenesis (Strauss, 1992), tumor progression and resistance to chemotherapy (Loeb, 1991; Yuan et al., 2000), and perhaps much of mutation-driven evolution generally. Yet, little direct evidence bears on most of these mutation mechanisms.
Adaptive mutation and amplification in Escherichia coli: Two pathways of genome adaptation under stress
2004, Research in Microbiology