Cataractogenesis: Developmental Inputs and Constraints
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Cited by (12)
Requirement for Crk and CrkL during postnatal lens development
2020, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Because the capsular components have very slow turnover rates, the continued deposition of matrix molecules results in a relatively thick membrane that continues to grow throughout life. The lens vastly increases in surface area from its initial formation to adulthood [7]. We generated a conditional mutation of both Crk and Crk-like (CrkL) in neuronal progenitor cells using a Nestin-Cre transgene [8] to investigate the role of these adaptor proteins in neurodevelopment at late stages of embryonic development.
The lens capsule
2009, Experimental Eye ResearchCitation Excerpt :This process also requires fusion of the edges of the basement membrane underlying the pit leading to a lens vesicle that is completely surrounded by the basement membrane, now properly called the lens capsule (Lovicu and McAvoy, 2005; Lovicu and Robinson, 2004; Parmigiani and McAvoy, 1984). This seals the developing lens off from direct contact with the surrounding ocular environment creating an immune privileged lens (Coulombre, 1979) protected from bacterial and viral invasion (Beyer et al., 1984; Cotlier et al., 1968; Karkinen-Jaaskelainen et al., 1975). However, the permeability of the lens capsule to water, small solutes and many proteins allows lens growth and metabolism to proceed (Fisher, 1977; Friedenwald, 1930a,b; Sabah et al., 2004, 2005).
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